This chapter focuses on the correlation between the key concepts of European political economy and interdependence. It elaborates on the interplay between multi-level governance, Europeanization, globalization, and EU market integration. Essentially, the EPE cannot be understood without careful analysis of the interlinkages between the EU market-building project and the region's interdependent relationships with the rest of the world. The chapter then provides an overview of the main concepts surrounding globalization, regionalization, and general trade patterns of national markets. It notes the high likelihood that EU-level agents, processes, and structures are prime shapers in any given aspect of the EPE.