This chapter examines U.S. foreign policy after 9/11 with a view to looking at continuities as well as the disjunctions of Washington’s engagement with the world. It first considers the impact of 9/11 on the United States, particularly its foreign policy, before discussing the influence of neo-conservatism on the making of U.S. foreign policy during the presidency of George W. Bush. It then analyses debates about the nature of U.S. foreign policy over the last few decades and its ability to create antagonisms that can and have returned to haunt the United States both at home and abroad. It also explores how increasing belief in the utility of military power set the parameters of U.S. foreign policy after 9/11, along with the U.S. invasion of Iraq, and concludes with an assessment of Barak Obama’s approach with regards to terrorism and his foreign policy agenda more generally.