This work examines how domestic politics and culture shape US foreign policy, with particular emphasis on the role of institutions and processes. It considers the ways in which pressure groups and elites determine influence what the United States does abroad, the importance of regional shifts and media and their impact on the making of US foreign policy, and US relations with Europe, the Middle East, Russia, the Asia-Pacific region, Latin America, and Africa. The text also discusses key issues relevant to American foreign policy, such as global terrorism, the global environment, gender, and religion. It argues that whoever resides in the White House will continue to give the military a central role in the conduct of US foreign policy, and that whoever ‘runs’ American foreign policy will still have to deal with the same challenges both at home and abroad.