This chapter discusses the complex and multifaceted relationship between science and politics. Although science and politics each follow a distinct logic and pursue distinct objectives, they are inextricably connected to one another. On the one hand, science influences political debates, by drawing attention to certain problems and providing necessary justifications for political action. On the other hand, political dynamics, including political values and power relations, structure the conduct of science. The chapter highlights the different aspects of the co-production of science and politics, in the framework of international environmental debates. An increasing number of studies on global environmental governance suggest that science and politics are co-produced. As they shape each other, it is impossible to understand one without considering the other. Political interactions are partly based on available knowledge, and scientific production is a social practice that is conditioned by its political context.