This chapter discusses diplomacy and the conduct of foreign policy, both of which are fundamental to relations between political communities worldwide. It first considers diplomacy and its related concept, statecraft, in global history, focusing on some important concepts such as raison d’état (reason of state) and machtpolitik (power politics). It then examines diplomatic practice in contemporary global politics, with particular emphasis on track-two diplomacy and third-party mediation, along with developments in diplomacy during the Cold War. It also looks at public diplomacy, which may be understood as an instrument of ‘soft power’ in contrast with the methods of power politics. It concludes with an overview of the European Union’s common foreign and security policy.