This chapter offers critical reviews of the explanatory power of identity and culture in understanding international relations in the Middle East. It focuses on Arabism and other regional ethnicities as sources of political identity. The importance of these identities within the region has been accentuated because of the poor fit between identity and states and regimes — a colonial legacy, but one that remains pertinent today, as revealed in the Arab uprisings. Indeed, the persistence of conflict in the Middle East must be understood through this ‘incongruence of identity and material structures’. Focusing on pan-Arabism, as well as the irredentist and separatist movements that have characterized the history and political development of the region, the chapter shows how the interaction of identity with state formation and development has contributed to numerous wars, and most recently to the evolution of regional developments following the Arab Spring.