Internal and external trade liberalization have together constituted the essence of European integration since the Treaty of Rome. Successive enlargements, along with the constant deepening of the single market, have turned the European Union (EU) into one of the world’s largest trade powers. The EU forms trade policy through a complex decision-making process, often contested politically, which allows it to speak on behalf of its members in international trade, and now investment, negotiations. This chapter argues that not only does the EU derive some inherent power from trade, but it has also long used trade as the backbone of its normative power, using its market access in order to obtain political concessions from its commercial partners. However, this role has been increasingly challenged by recent changes in the relative power and behaviour of the EU’s main trade partners and competitors, which have forced Europe to refocus its trade policy towards more traditional commercial objectives and to create new unilateral trade defence instruments. Through its goal of what is terms open strategic autonomy, the EU is trying to strike a delicate balance between remaining a force for liberalism and openness in the world while not being naive and taken advantage of. This chapter explores the determinants of the EU’s trade power and examines the contribution of trade policy to the power of Europe in the international system, both in the context of international trade agreements and in the broader framework of international relations.