This chapter discusses W.E.B. Du Bois’s political thought and strategies for political advocacy which primarily focus on the politics of race, colonialism, gender, and labour. It also explains the key concepts in Du Bois’s criticism of how the white supremacist ideology shaped modern societies to create the colour line and to exclude members of vulnerable groups. These concepts include the doctrine of racialism, double consciousness, and Pan-Africanism. The chapter recognizes Du Bois’s contributions to Black feminist thought and American labour politics, which inspired major social justice movements in the twentieth century. Thus, Du Bois’s political thought shored up the contradictions in the liberal principles of freedom and equality for all.