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This chapter discusses the importance of politics to the relationship between human rights and development. It describes the two major ways in which human rights struggles have focused on development processes in the last two decades: the right to development, the struggles of poor countries for a better deal in the global economic system; and the human rights-based approach to development, the struggles of poor people for development to realize their rights. The chapter first considers the links between human rights, politics, and development before analysing the concepts and debates surrounding the right to development and the human rights-based approach to development. It then presents a case study on the Millennium Development Goals and the successor, Sustainable Development Goals, to illustrate how human rights principles are raised in contemporary debates on development priorities.