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This chapter examines the role of developing countries in international politics. International relations, as a discipline, has traditionally overlooked the significance of the developing world in global politics. The chapter begins by discussing the reasons for this and why such an oversight is lamentable. It then considers the position of the developing world throughout the large structural changes that have occurred in the international system since 1945: North–South relations during and after the Cold War and the emerging multipolar world, in which China is anticipated to return to the centre of international politics. The chapter also explores topics such as the United Nations’s involvement in development issues and its role in decolonization, U.S. foreign policy under the two Obama administrations, and nuclear proliferation.