This chapter analyses the United Kingdom’s departure from the European Union (EU), commonly known as Brexit. The chapter examines the historical context that shaped the UK’s decision to join the European Economic Community (EEC) and its subsequent relationship with the EU. It charts the events leading to the 2016 EU referendum, including the campaign and explains the reasons for the narrow Leave vote. The Withdrawal Agreement (WA) negotiations under Article 50 are discussed by focusing on process, actors, and outcomes. This is followed by an evaluation of the negotiations leading to the signing of the Trade and Cooperation Agreement (TCA) and its implications. The chapter ends by discussing the impact and implications of the UK’s departure from the EU.