This chapter addresses global production, which has powerful effects on the incomes, working conditions, and development opportunities of populations around the world. It is not surprising that the organization and regulation of global production have become one of the most contentious subjects of debate within the field of Global Political Economy (GPE). The chapter confronts several difficult questions linked to these debates. Who does the work of global production, and how has its organization changed over time? Who exercises power within evolving systems of global production, and what winners and losers do such arrangements produce? How is global production governed, and with what consequences for labour rights and the environment? In exploring these questions, analytical lenses drawn from a range of political economy perspectives help us to make sense of the complex economic and political forces through which the organization and governance of contemporary global production is shaped and contested.