This chapter explores the various disciplinary and political dimensions of Donna Haraway’s work revolving around the negotiation of the interdisciplinary problem of the Anthropocene. It considers Haraway’s works which range between feminist interventions in science studies, animal studies, and environmental criticism. Haraway’s A Cyborg Manifesto (1985) offers a feminist response to broadly Marxist accounts of the relationship between technology and history while also reconfiguring and responding to feminist forms of socialism. After briefly introducing Haraway’s contributions to standpoint theory and posthumanism, this chapter turns to an examination of her critique of science and her alternative way of considering the world in which the boundaries between the human and non-human disappear. Haraway outlines various ways to think about planetary change and develops a conception of the Chthulucene that captures the complexity of the present, including the transformation of nature through human histories.