This chapter examines the ramifications of genocide for human rights. Genocide is one of the most extreme forms of human rights violations, but its definition has been the subject of considerable debate. In recent years, there have been efforts to develop a better policy on genocide prevention. This chapter evaluates various definitions of genocide as well as some of the weak points of the 1948 United Nations Convention on the Punishment and Prevention of the Crime of Genocide, also known as the Genocide Convention. It also discusses theories of why genocide occurs and concludes with case studies of Rwanda and Darfur, both of which describe the background to the mass violence in both locations, as well as the international responses.