Abstract
This chapter outlines how the international community tries to address cross-border health concerns through its system of global health governance. It looks at the historical evolution and contemporary context of the global health governance system. In order to delve more deeply into the strengths and weaknesses of the current system, the chapter looks at the COVID-19 pandemic to assess how various national and international actors responded and where they ran into problems fomenting cooperation in the face of a global microbial threat.